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Hence intracellular proteins usually do not contain disulfides, which are abundant in extracellular proteins (such as those found in blood) or in certain organelles such as the endoplasmic reticulum and mitochondrial intermembrane space where disulfidesc can be introduced
Journal of Medicinal Chemistry (2021) 7
It stabilizes IkB-alpha, blocks p65 nuclear translocation, and suppresses MAPK activation, effectively turning off the transcriptional program that drives sustained inflammation
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